Using systematic reviews and meta-analyses to support regulatory decision making for neurotoxicants: lessons learned from a case study of PCBs Utilizando revisões sistemáticas e meta-análise de apoio às decisões regulatórias para neurotóxicos: lições de um estudo de caso dos PCBs

* This article was originally publisched by Environ Health Perspect 118:727–734 (2010). doi:10.1289/ehp.0901835 [Online 22 February 2010] and is part of the scientific collaboration between Cienc Saude Coletiva and EHP. 1 Department of Epidemiology, Emory University School of Public Health, Atlanta, Georgia, USA; 2 Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA; 3 Department of Psychology, and 4 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; 5 Center for Autism Spectrum Disorders, Children’s National Medical Center, Washington, DC, USA; 6 Department of Pediatrics, 7 Department of Psychiatry, and 8 Department of Neurology, George Washington University School of Medicine, Washington, DC, USA; 9 Center for Development and Learning, Kennedy Krieger Institute, Baltimore, MD, USA; 10 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; 11 Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA; 12 LaKind Associates, LLC, Catonsville, Maryland, USA; 13 Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA; 14 Department of Pediatrics, Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, Pennsylvania, USA. Address correspondence to LaKind Associates. LLC, 106 Oakdale Ave. 21228 Catonsville MD USA. [email protected] Using systematic reviews and meta-analyses to support regulatory decision making for neurotoxicants: lessons learned from a case study of PCBs